With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6624-49-3,Isoquinoline-3-carboxylic acid,as a common compound, the synthetic route is as follows.
Oxalyl chloride (91 muL, 1.04 mmol, 1.8 eq) was added dropwise to a mixture of isoquinoline-3-carboxylic acid (100 mg, 0.58 mmol, 1.0 eq) and DMF (5 muL, 0.06 mmol, 0.1 eq) in DCM (1.7 mL). The reaction was stirred for 2 hrs. The reaction was concentrated under reduced pressure to give a yellow residue of isoquinoline-3-carbonyl chloride, which was used in the next step without purification.
The synthetic route of 6624-49-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ENANTA PHARMACEUTICALS, INC.; WANG, Guoqiang; GRANGER, Brett; SHEN, Ruichao; HE, Yong; XING, Xuechao; MA, Jun; LONG, Jiang; HE, Jing; WANG, Bin; OR, Yat, Sun; (131 pag.)WO2018/218042; (2018); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem