With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1350643-72-9,(S)-3-(1-Aminoethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one,as a common compound, the synthetic route is as follows.
[401] To a suspension of (5)-3-(l-aminoethyl)-8-chloro-2-phenylisoquinolin-l(2H)-one (51.3 mg, 0.172 mmol), 6-chloro-5-(3-ethyl-l,2,4-oxadiazol-5-yl)pyrimidin-4-amine (46.3 mg, 0.205 mmol) and DIPEA (29.9 mg, 0.231mmol) in propan-l-ol (2.0 mL), and then the mixture was heated at 100 C with stirring for 5 hours. The mixture was concentrated in vacuo and the residue was purified by a silica gel column chromatography (DCM/MeOH (v/v) = 100/1) to give the title compound as a pale yellow solid (54 mg, 65%). MS (ESI, pos. ion) m/z: 487.8 [M+H]+; NMR (400 MHz, CDCb) delta (ppm): 8.32 (d, J= 5.8 Hz, 1H), 8.02 (s, 1H), 7.55-7.39 (m, 6H), 7.33 (t, J = 8.4 Hz, 2H), 6.51 (s, 1H), 5.10-4.83 (m, 1H), 2.85 (q, J = 7.5 Hz, 2H), 1.44 (d, J = 6.7 Hz, 3H), 1.38 (t, J= 7.5 Hz, 3H)., 1350643-72-9
1350643-72-9 (S)-3-(1-Aminoethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one 66607319, aisoquinoline compound, is more and more widely used in various.
Reference£º
Patent; SUNSHINE LAKE PHARMA CO., LTD.; CALITOR SCIENCES, LLC; XI, Ning; WANG, Tingjin; FENG, Xuejin; WU, Shuang; ZHANG, Tao; WANG, Liang; (139 pag.)WO2016/149160; (2016); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem