893566-75-1, Tert-butyl 8-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,893566-75-1
A mixture of tert-butyl 8-bromo-3,4-dihydroiso- quinoline-2(1H)-carboxylate (500 mg, 1.60 mmol), Nal (720 mg, 4.80 mmol), Cul (45.8 mg, 0.240 mmol) and trans-N,Ndimethylcyclohexanediamine (68 mg, 0.48 mmol) in dioxane (10 mE) was purged with N2 for 10 mm. The resulting yellow suspension was stirred at 110¡ã C. in a sealed tube for 20 hrs. ECMS showed 50percent conversion, therefore additional Nal (720 mg, 4.80 mmol), Cul (45.8 mg, 0.24 mmol) and trans-N,N-dimethylcyclohexanediamine (68 mg, 0.40 mmol) was added followed by N2 purging for 10 mm. The resulting yellow suspension was stirred at 110¡ã C. in a sealed tube for 20 hrs. The mixture was poured into water (20 mE) and extracted with EtOAc (10 mEx3). The extract was concentrated in vacuo to afford crude material which was purified by silica gel chromatography eluted with EtOAc in petroleum ether from 0 to 20percent to afford the product (450 mg, 78percent) as a light yellow oil. ECMS [M-tBu]304; 1H NMR (400 MHz, CDCl3) oe ppm 7.70 (d, J=8.0 Hz, 1H), 7.12 (d, J=7.0 Hz, 1H), 6.94-6.82 (m, 1H), 4.44 (m, 2H), 3.62 (t, J=5.5 Hz, 2H), 2.81 (br. s., 2H), 1.50 (s, 9H)
The synthetic route of 893566-75-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Pfizer Inc.; Tatlock, John Howard; McAlpine, Indrawan James; Tran-Dube, Michelle Bich; Rui, Eugene Yuanjin; Wythes, Martin James; Kumpf, Robert Arnold; McTigue, Michele Ann; (181 pag.)US2016/244475; (2016); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem