70810-24-1,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.70810-24-1,1,7-Dichloroisoquinoline,as a common compound, the synthetic route is as follows.
A mixture of the appropriate chloride (Vila) or (VIIb) (ex: 5-chloro-N-(2-chloropyridin-4-yl)isoquinolin-1 -amine) (1 eq), the appropriate amine NH2-PG1(ex: tert-butyl carbamate)(1.5 eq), Pd2(dba)3 (0.1 eq), XantPhos (0.2 eq) and cesium carbonate (2 eq) in dioxane (5.3 mL/mmol) (pre- degasified) was heated at 140C for 2-5h under nitrogen atmosphere. The mixture was filtered through a celite pad and concentrated under reduced pressure. Alternatively, extractionwith ethyl acetate, washing with brine and drying with sodium sulphate was also performed. The residue was purified by flash column chromatography (dichloromethane/methanol or hexanes/ethyl acetate) to obtain the desired product (Villa) or (VII Ib) (ex: tert-Butyl (4-((5-chloroisoquinolin-1 – yl)am ino)pyridin-2-yl)carbamate). HPLC-MS (method A): Rt= 2.30 mm, [M+H] mlz 371 373. Yield: next step without purification.
70810-24-1 1,7-Dichloroisoquinoline 640956, aisoquinoline compound, is more and more widely used in various.
Reference£º
Patent; MINORYX THERAPEUTICS S.L.; GARCIA COLLAZO, Ana Maria; MARTINELL PEDEMONTE, Marc; REVES VILAPLANA, Marc; LAVILLA GRIFOLS, Rodolfo; RODRIGUEZ PASCAU, Laura; CUBERO JORDA, Elena; (136 pag.)WO2016/120808; (2016); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem