With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.891785-28-7,6-Bromoisoquinolin-3-amine,as a common compound, the synthetic route is as follows.
891785-28-7, A mixture of 6-bromoisoquinolin-3-amine (XV) (2.57 g, 11.52 mmol), 1-methyl-5-(tributylstannyl)-1H-imidazole (LXXI) (Combi-blocks) (4.28 g, 11.53 mmol), Pd(PPh3)4 (1.39 g, 1.2 mmol) in dioxane (57.6 mL) was purged with N2 gas for 10 min and then heated to 90 C. overnight. The solvent was evaporated under high vacuum and the residue was purified by column chromatography (0?10% MeOH/CHCl3) to give 6-(3-methylimidazol-4-yl)isoquinolin-3-amine (LXXII) as an olive green solid (2.32 g, 9.83 mmol, 85.3% yield). ESIMS found for C13H12N4 m/z 225.1 (M+H).
As the paragraph descriping shows that 891785-28-7 is playing an increasingly important role.
Reference£º
Patent; Samumed, LLC; KC, Sunil Kumar; Mittapalli, Gopi Kumar; Chiruta, Chandramouli; Hofilena, Brian Joseph; Mak, Chi Ching; Eastman, Brian Walter; Bollu, Venkataiah; (158 pag.)US2019/119263; (2019); A1;,
Isoquinoline – Wikipedia
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