With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34784-05-9,6-Bromoisoquinoline,as a common compound, the synthetic route is as follows.
A round bottom flask charged with 6-bromo isoquinoline (prepared from 4-bromobenzaldehyde according to the literature: Neiko Nerenz, et al. (1998) J. Chien7. Soc. Perkin Trans. 2,437-447, 0.200 g, 0.961 mmol), 1-Boc piperazine (0.215 g, 1.15 mmol), K3PO4 (0.286 g, 1.35 mmol), (2′-dicyclohexylphosphanyl-biphenyl-2-yl)-dimethylamine (0.028 g, 0.072 mmol) and Pd2dba3 (0.022 g, 0.024 mmol) in dry DME (2 mL) was purged under N2 and heated at reflux for 5 hours. After cooling, the mixture was partitioned between EtOAc and H20. The organic layer was washed with brine, dried and concentrated. The residue was purified by column chromatography (1: 1 hexanes/EtOAc, ) to give 4-Isoquinolin-6-yl-piperazine-1- carboxylic acid tert-butyl ester (0.210 g, 70%) as a white solid. 1H NMR (CDC13, 400 MHz) 5 9.04 (s, 1H), 8.39 (dd, J= 6.8 Hz, J= 2. 8 Hz, 1H), 7.83 (dd, J= 9.2 Hz, J= 2.8 Hz, 1H), 7.45 (d, J= 6.8 Hz, 1H), 7.32 (dd, J= 9.2 Hz, J= 2.4 Hz, 1H), 6.98 (s, 1H), 3.64 (m, 4H), 3.35 (m, 4H), 1.50 (s, 9H). LCMS (APCI+) mlz 314 [M+H] + ; Rt = 2.14 minutes., 34784-05-9
The synthetic route of 34784-05-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ARRAY BIOPHARMA INC.; WO2005/51304; (2005); A2;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem