With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.82827-09-6,6-Bromoisoquinolin-1(2H)-one,as a common compound, the synthetic route is as follows.
82827-09-6, 6-Bromo-2-(4-methoxy-benzyl)-2H-isoquinolin-1-one (13); 28.18 g (125.8 mmol) 6-bromo-2H-isoquinolin-1-one (6) were dissolved in 200 ml dimethylacetamide and 7.55 g (188.7 mmol) sodium hydride (60%) were added at room temperature. After stirring for 30 minutes, 29.94 g (188.7 mmol) 4-methoxy- benzylchloride were added and stirring was continued at room temperature until complete conversion was detected. The solvent was removed under reduced pressure, the residue taken up in saturated NaHCO3-solution and extracted three times with dichloromethane. The organic layers were dried with MgSO4 and evaporated. Final purification was achieved by silicagel chromatography. Rt = 1.93 min (Method B). Detected mass: 344.1 (M+H+).
As the paragraph descriping shows that 82827-09-6 is playing an increasingly important role.
Reference£º
Patent; SANOFI-AVENTIS; WO2008/77553; (2008); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem