23687-26-5, 6-Aminoisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
K3PO4 (0.444 g, 2.092 mmol), Pd2(dba)3 (0.040 g, 0.0436 mmol) and Xantphos (0.042 g, 0.0726 mmol) were added to a solution of intermediate 11 (0.137 g, 0.726 mmol) in THF (6 mL) while nitrogen was bubbling. After 10 min, isoquinolin-6-amine (0.105 g, 0.726 mmol) was added and the mixture was stirred at rt for 10 min. Then, the mixture was heated at 100 ¡ãC for 16 h. More Pd2(dba)3 (0.026 g, 0.0289 mmol) and Xantphos (0.028 g, 0.0481 mmol) were added while nitrogen was bubbling through the mixture, after which it was further heated at 100 ¡ãC overnight. The mixture was washed with aq. sat. NaHC03 and extracted with EtOAc. The combined organic layers were dried over MgSC , filtered and the solvent was evaporated in vacuo. The crude product was purified by flash column chromatography (silica; EtOAc in DCM 0/100 to 65/35). The desired fractions were collected and concentrated in vacuo. The product was further purified by preparative HPLC (from 70percent [25 mM NH4HCO3] – 30percent [ACN: MeOH (0213) 1 : 1] to 27percent [25 mM NH4HCO3] – 73percent [ACN: MeOH 1 : 1]). The desired fractions were collected and the solvent was evaporated. The product was triturated with Et20 and filtrated to yield compound 6 (0.092 g, 43percent). NMR (300 MHz, DMSO-d6) delta ppm 2.93 (s, 3 H) 3.62 (dt, J=26.7, 4.6 Hz, 2 H) 4.60 (dt, J=47.7, 4.7 Hz, 2 H) 6.93 (d, J=9.1 Hz, 1 H) 7.28 (dd, J=9.0, 2.7 Hz, 1 H) 7.46 – 7.60 (m, 2 H) 7.82 – 7.94 (m, 2 H) 8.27 (d, J=5.8 Hz, 1 H) 8.34 (s, 1 H) 8.97 (s, 1 H) 9.21 (s, 1 H), 23687-26-5
23687-26-5 6-Aminoisoquinoline 588991, aisoquinoline compound, is more and more widely used in various fields.
Reference£º
Patent; JANSSEN PHARMACEUTICA NV; ANDRES-GIL, Jose, Ignacio; BORMANS, Guy, Maurits, R.; DECLERCQ, Lieven, Denis, Herwig; FIERENS, Katleen; LEENAERTS, Joseph, Elisabeth; MOECHARS, Diederik, Willem, Elisabeth; ROMBOUTS, Frederik, Jan, Rita; KOLB, Hartmuth; ZHANG, Wei; (67 pag.)WO2018/15307; (2018); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem