With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23687-25-4,Isoquinolin-4-amine,as a common compound, the synthetic route is as follows.,23687-25-4
Isoquinolin-4-amine (50 mg, 0.347 mmol), phenyl (4-methyl-3-(l-methyl-6- oxo-l,6-dihydropyridin-3-yl)-l-phenyl-lH-pyrazol-5-yl)carbamate (Intermediate 5, 99.2 mg, 0.248 mmol) and NEt3 (104 mu, 0.743 mmol) were combined in DMF (0.2 mL) and stirred ambient temperature overnight. The mixture was loaded onto a samplet and purified by reverse-phase column chromatography, eluting with 0-70% acetonitrile/water, to afford the title compound (52 mg, 0.115 mmol, 47% yield). MS (apci) m/z = 451.2 (M+H).
The synthetic route of 23687-25-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ARRAY BIOPHARMA INC.; ALLEN, Shelley; BLAKE, James F.; BRANDHUBER, Barbara J.; JIANG, Yutong; KOLAKOWSKI, Gabrielle R.; XU, Rui; WINSKI, Shannon L.; WO2014/78328; (2014); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem