23707-37-1, Isoquinolin-7-amine is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a mixture of 7-[(2-chloro-pyridine-3-carbonyl)-amino]-4,4-dimethyl-3,4-dihydro-lH-isoquinoline-2-carboxylicacid tert-butyl ester (20.8 g, 50 mmol, 1.0 eq.), 7-aminoisoquinoline (7.2 g, 50 mmol, 1.0 eq.), Pd2(dba)3 (915mg, lmmol,0.02 eq), 2-dicyclohexylphosphino-2′-(N,N-dimethylamino)biphenyl (CASNo. 213697-53-1, Strem Chemicalscat no. 15-1145; 785 mg, 2 mmol, 0.04 eq) under N2 in a 250mL pressure reaction vessel was added 1.0 M LiNTMS2 THFsolution (120 mL, 120 mmol, 2.4 eq.). The reaction vesselwas sealed with a Teflon screwcap and the mixture wasstirred at 70 SC for 17 h. The mixture was then cooled toRT. 100 mL of water was added to the mixture and the mixturewas extracted with 500 mL of EtOAc. The organic layer waswashed with sat. NH4C1 solution, 1M NaHP04 solution (4x200mL) then dried over MgS04. After filtration andconcentration, the crude was purified through a silica gelcolumn chroma tography, eluting with CH2Cl2/EtOAc. Thedesired title compound was obtained as a yellow solid. MS(ES+) : 524 (M+H) + . Calc’d for CsiHssNsOs- 523.26, 23707-37-1
As the paragraph descriping shows that 23707-37-1 is playing an increasingly important role.
Reference£º
Patent; AMGEN INC.; WO2006/12374; (2006); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem