891785-28-7, 6-Bromoisoquinolin-3-amine is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
891785-28-7, Step a. To a solution of 6-bromoisoquinolin-3 -amine (0.20 g, 0.89 mmol) and 4-(4,4,5,5- tetramethyl-l,3,2-dioxaborolan-2-yl)-lH-pyrazole (0.19 g, 0.98 mmol) in DMF : water (4: 1, 5 ml) was prepared in a microwave glass vial. CS2CO3 (0.87 g, 2.68 mmol) was added to the reaction mixture at rt. The reaction mixture was degassed at rt for 15 min before adding Pd(dppf)Cl2 (0.06 g, 0.09 mmol) and the glass vial was sealed. The reaction mixture was subjected to microwave heating at 150C for 1 h. The resulting reaction mixture was poured into water (50 ml) and extracted with EtOAc (3 x 50 ml). The combined organic layer was washed with brine solution (50 ml), dried over Na2SC>4, filtered and concentrated under reduced pressure. The resulting residue was purified by column chromatography (2.2% MeOH in DCM) yielding 6-(lH-pyrazol-4-yl) isoquinolin-3 -amine (0.1 1 g, 0.52 mmol). LCMS: Method A, 1.47 min, MS: ES+ 211.18.
891785-28-7 6-Bromoisoquinolin-3-amine 45789831, aisoquinoline compound, is more and more widely used in various fields.
Reference£º
Patent; MISSION THERAPEUTICS LTD; JONES, Alison; KEMP, Mark Ian; STOCKLEY, Martin Lee; GIBSON, Karl Richard; WHITLOCK, Gavin Alistair; MADIN, Andrew; (217 pag.)WO2016/46530; (2016); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem