891782-60-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.891782-60-8,7-Bromo-3,4-dihydro-2H-isoquinolin-1-one,as a common compound, the synthetic route is as follows.
To a stirred suspension of Sodium Hydride (NaH) (60% in oil, 115 mg, 2.83 mmol, 1.2 eq.) in Dimethylformamide (DMF, 5 mL) was added a solution of 7-bromo-3, 4-dihydro i soquinolin- 1 (2H)-one (500 mg, 2.36 mmol, 1.0 eq.) in DMF (5 mL), and the resultant mixture was stirred at ambient temperature for 1 hour. A solution of 1 -chl oro-3 -(3 , 4-dihydroi soquinolin- 2(lH)-yl)propan-2-ol (650 mg, 2.83 mmol, 1.2 eq.) in DMF (5 mL) was added, and the resultant mixture was heated to 70 C for additional 3 hours. The reaction mixture was treated with water and EA, and organic phase was separated. Organic phase was washed with water, dried over Na2S04, and was concentrated to dryness. The crude material was purified by a column chromatography (200-300 mesh silica gel, PE/EA = 2/1) to afford 7 -bromo-2-(3-(3, 4-dihydro isoquinolin-2(lH)-yl)-2-hydroxypropyl)-3,4-dihydroisoquinolin-l(2H)-one (270 mg, 28% yield) as a yellowish oil.
891782-60-8 7-Bromo-3,4-dihydro-2H-isoquinolin-1-one 25067330, aisoquinoline compound, is more and more widely used in various fields.
Reference£º
Patent; PHARMABLOCK SCIENCES (NANJING), INC.; LIU, Liu; LI, Jin; YANG, Minmin; (126 pag.)WO2019/173804; (2019); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem