With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.891785-28-7,6-Bromoisoquinolin-3-amine,as a common compound, the synthetic route is as follows.
891785-28-7, Step 1 To a stirred suspension of 6-bromoisoquinolin-3-amine (XX)(1.0 g, 4.48 mmol)in DMF (15 mL)at 0 C. was added 1-chloropyrrolidine-2,5-dione (XXI)(598.6 mg, 4.48 mmol)portionwise. The mixture was stirred at 0 C. for 6 h. The reaction mixture was added to water (150 mL), stirred for 1 h and the resulting solids were collected by filtration and air dried overnight to obtain 6-bromo-4-chloro-isoquinolin-3-amine (XXII)(922 mg, 3.58 mmol, 79.9% yield)as a beige solid which was used for next step without purification. 1H NMR (499 MHz, DMSO-d6)delta ppm 6.55 (2H, s), 7.40 (1H, dd, J=8.64, 1.78 Hz), 7.88 (1H, d, J=8.51 Hz), 7.90 (1H, d, J=1.10 Hz), 8.86 (1H, s); ESIMS found for C9H6BrClN2m/z 256.9 (79BrM+H).
The synthetic route of 891785-28-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Samumed, LLC; KC, Sunil Kumar; Mak, Chi Ching; Eastman, Brian Walter; Cao, Jianguo; Bollu, Venkataiah; Mittapalli, Gopi Kumar; Chiruta, Chandramouli; (218 pag.)US2017/313682; (2017); A1;,
Isoquinoline – Wikipedia
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