With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.80278-67-7,Isoquinoline-5-carbaldehyde,as a common compound, the synthetic route is as follows.
80278-67-7, To an ice-cold solution of isoquinoline-5-carbaldehyde2 (0.68 g, 4.3 mmol) in MeOH (15 mL) was added NaBH4 (0.17 g, 4.6 mmol), and the reaction mixture was stirred for 15 min. The reaction was quenched with brine, the solvent was removed under reduced pressure, and the residue was dissolved in EtOAc. The organic solution was washed with water and then brine, dried (NA2S04), filtered, and concentrated under reduced pressure to afford isoquinolin-5- ylmethanol as a brown solid (0.63 g, 93percent) :H NMR (300 MHz, DMSO-D6) 8 9.87 (s, 1H), 8.82 (d, J = 6 Hz, 1H), 8.57 (d, J= 6 Hz, 1H), 8.47 (d, J = 9 Hz, 1H), 8. 30 (d, J = 6 Hz, 1H), 7.95 (t, J = 9 Hz, 1H), 5.34 (s, 2H).
As the paragraph descriping shows that 80278-67-7 is playing an increasingly important role.
Reference£º
Patent; PHARMACIA CORPORATION; WO2005/18557; (2005); A2;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem