164148-92-9, tert-Butyl 6-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
At room temperature,6-amino-3,4-dihydroisoquinolin-2 (1H) -carboxylic acid, t-butyl ester (500 mg)Triethylamine (0.337 mL)And THF (10 mL)Was added 2,2,2-trichloroethyl chloroformate (0.333 mL)The resulting mixture was stirred in a nitrogen atmosphere,Stir at the same temperature for 10 minutes.At room temperature, water was added to the reaction mixture,And the aqueous layer was extracted with ethyl acetate.The extract was washed with water and brine and dried over anhydrous magnesium sulfate,And the solvent was removed by distillation under reduced pressure.A solution of 4M hydrochloric acid in ethyl acetate (5 mL) was added to a mixture of the residue and ethyl acetate (5 mL) at room temperature, and the resulting mixture was stirred under nitrogen atmosphere for 3 days.The precipitate was collected by filtration and washed with ethyl acetate to give the title compound (652 mg).
164148-92-9, The synthetic route of 164148-92-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; TAKEDA PHARMACEUTICAL COMPANYLIMITED; HIRAYAMA, TAKAHARU; FUJIMOTO, JUN; CARY, DOUGLAS ROBERT; OKANIWA, MASANORI; HIRATA, YASUHIRO; (289 pag.)TW2017/14883; (2017); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem