164148-92-9, tert-Butyl 6-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of 9c (407 mg, 1.78 mmol), tert-butyl 6-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate (39a, 494 mg, 1.99 mmol), HATU (889 mg, 2.34 mmol), DIEA (0.70 mL, 4.01 mmol), and DMF (3 mL) was stirred at rt for 13 h. The reaction mixture was diluted with EtOAc (60 mL), and washed with sat. aq. NaHCO3 (2 ¡Á 30 mL) and brine (2 ¡Á 30 mL). The organic layer was dried over MgSO4 and evaporated solvent under vacuum. The resulting residue was purified by column chromatography (silica gel, eluted with 5% MeOH/EtOAc) and crystallization from EtOAc to yield 40a (623 mg, 76%) as a white solid. 1H NMR (300 MHz, DMSO-d6) delta 1.43 (9H, s), 2.77 (2H, t, J = 5.8 Hz), 3.55 (2H, t, J = 5.8 Hz), 3.94 (3H, s), 4.46 (2H, s), 6.84 (1H, d, J = 15.6 Hz), 7.13 (1H, d, J = 8.3 Hz), 7.41-7.53 (2H, m), 7.59 (1H, s), 7.67-7.78 (2H, m), 8.08 (1H, s), 8.53 (1H, d, J = 5.3 Hz), 8.77 (1H, s), 10.24 (1H, s). MS (API): m/z 460.1 (M + H)+.
164148-92-9, 164148-92-9 tert-Butyl 6-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate 2756371, aisoquinoline compound, is more and more widely used in various fields.
Reference£º
Article; Fujimoto, Jun; Hirayama, Takaharu; Hirata, Yasuhiro; Hikichi, Yukiko; Murai, Saomi; Hasegawa, Maki; Hasegawa, Yuka; Yonemori, Kazuko; Hata, Akito; Aoyama, Kazunobu; Cary, Douglas R.; Bioorganic and Medicinal Chemistry; vol. 25; 12; (2017); p. 3018 – 3033;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem