34784-05-9, 6-Bromoisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
EXAMPLE 38; N-(2-chloro-5-(6-isoquinolinyl)-3-pyridinyl)-4-fluorobenzenesulfonamide; (Some starting materials may be obtained from Kalexsyn, Kalamazoo, MI) A glass microwave reaction vessel was charged with 6-bromoisoquinoline (120 mg, 0.58 mmol), N- (2-chloro-5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)pyridin-3-yl)-4- fluorobenzenesulfonamide (262 mg, 0.6 mmol), l,l’-bis(diphenylphosphino)ferrocene-palladium dichloride (32 mg, 0.04 mmol), sodium carbonate (183 mg, 1.730 mmol), and dioxane-H2O(2: l, 3 mL). The reaction mixture was sealed and heated at 1000C for 1 h. Water was added in, and the suspension was filtered, the solid was air-dry. The crude product was chromatographed through a Redi-Sep pre-packed silica gel column (40 g), eluting with a gradient of 2% to 5% MeOH in CH2Cl2 to provide N-(2-chloro-5-(isoquinolin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide (20 mg, 8.4% yield) as a white solid. MS (ESI pos. ion) m/z: calc’d for C20Hi3ClFN3O2S:413.0;
34784-05-9, As the paragraph descriping shows that 34784-05-9 is playing an increasingly important role.
Reference£º
Patent; AMGEN INC.; WO2009/155121; (2009); A2;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem