With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34784-05-9,6-Bromoisoquinoline,as a common compound, the synthetic route is as follows.
Specific preparation methods are: no special protection, clean air to a single-necked flask were added sequentially magneton, 6-bromo-isoQuinoline (83.2mg, 0.4mmol), added elemental iodine (20mg, 20mol%), 70% of the mass fraction of the water phase of t-butylperoxyHydrogen (152mg, 1.2mmol), then add toluene (728.8mg, 8mmol), toluene as both reactant and as a solvent, at 150 After 1 hour TLC showed the starting material 6-bromo-isoquinoline consumed completely. Heating was stopped to quench the reaction. Without CraftsTake on a wet sample directly, 200-300 mesh silica gel column chromatography, a mixed solvent of ethyl acetate and petroleum ether (1: 6) rinse. SeparateA compound of formula VIIIa structural formula 92.6mg, 74% yield;
34784-05-9, As the paragraph descriping shows that 34784-05-9 is playing an increasingly important role.
Reference£º
Patent; Xiangtan University; Yang, Luo; Luo, Wenkun; (17 pag.)CN105503724; (2016); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem