With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.622867-52-1,tert-Butyl 6-(hydroxymethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate,as a common compound, the synthetic route is as follows.,622867-52-1
A stirred mixture oftert-butyl 6-(hydroxymethyi)-3,4-dihydroisoquinoiine-2(1H)-carboxylate (8.0 g, 30.4 mrnoi) inDCM (100 mL) was added Mn02 (21.2 g. 243.8 mmoi). The mixture was stirred under reflux for16 h. The mixture was filtered and concentrated in vacuo, the crude product was purified bysilica gel chromatography (PE/:EtOAc =100:1 1 0: 1) to afford the title compound.
622867-52-1 tert-Butyl 6-(hydroxymethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 59132278, aisoquinoline compound, is more and more widely used in various fields.
Reference£º
Patent; MERCK SHARP & DOHME CORP.; ADAMS, Gregory, L.; COX, Jason, M.; DEBENHAM, John, S.; EDMONDSON, Scott; GILBERT, Eric, J.; GUO, Yan; JIANG, Yu; JOSIEN, Hubert; KIM, Hyunjin, M.; LAN, Ping; MIAO, Shouwu; PLUMMER, Christopher, W.; RAJAGOPALAN, Murali; SHAH, Unmesh; SUN, Zhongxiang; TRUONG, Quang, T.; UJJAINWALLA, Feroze; VELAZQUEZ, Francisco; VENKATRAMAN, Srikanth; SUZUKI, Takao; WANG, Nengxue; (182 pag.)WO2017/205193; (2017); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem