With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18881-17-9,(S)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol,as a common compound, the synthetic route is as follows.
18881-17-9, This derivative is obtained using a literature protocol (RB et al Kawthekar South Africa Journal of Chemistry 63, 195, 2009) from 15 g of (35) – 1,2,3, 4- ttrahydiOisoquinolin-3-y nthanol (91.9 mmol) in the presence of benzyl chloroformate and triethylamine in dichloromethane solution.After purification on silica gel (petroleum ether / AcOEt gradient), the title product is obtained as an oil.
As the paragraph descriping shows that 18881-17-9 is playing an increasingly important role.
Reference£º
Patent; France Servier Pharmaceuticals; p, Casara; T, Le Diguaher; J-M, Henlin; J-B, Starck; A, Le Tiran; G, De Nanteuil; O, Geneste; J¡¤E¡¤P, Davidson; J¡¤B, Murray; I-J, Chen; C, Walmsley; C¡¤J, Graham; S, Ray; D, Maddox; S, Bedford; (116 pag.)CN105408321; (2016); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem