1125-80-0, 3-Methylisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step 2: 2-BenzyI-3-methyl-l-(4-(trifluoromethyl)phenyl)-l,2,3,4-tetrahydro- isoquinoline; To a solution of 3-methylisoquinoline (1.0 g, 6.98 mmol) in THF (6 mL) was added benzyl bromide (0.78 mL, 6.63 mmol). After the addition was completed, the mixture was heated at 70 0C under N2 for 16 h. The mixture was cooled down to RT and THF (10 mL). Then, the mixture was cooled to 0 0C and (4- (trifluoromethyl)phenyl)magnesium bromide was added, and then stirred at RT for 16 h. After quenching with saturated ammonium chloride solution, the mixture was extracted several times with EtOAc. The combined organic extracts were dried over MgSO4 and concentrated. The residue was mixed with silica gel and the solid mixture was purified by silica gel flash column chromatography (30%- 100% EtO Ac/hexane, then 20% MeOH in DCM) to give a mixture of 2-benzyl-3 – methyl- 1 -(4-(trifluoromethyl)phenyl)-l ,2-dihydroisoquinoline & 2-benzyl-3- methyl-l-(4-(trifluoromethyl)phenyl)-isoquinolinium, which was used without further purification., 1125-80-0
1125-80-0 3-Methylisoquinoline 14306, aisoquinoline compound, is more and more widely used in various fields.
Reference£º
Patent; AMGEN INC.; WO2009/73203; (2009); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem