190777-77-6, 5-Bromoisoquinolin-1(2H)-one is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
5-Bromoisoquinolin-1(2H)-one (501 mg, 2.23 mmol) was dissolved in DMF (10 mL), and sodium hydride (134 mg, 3.35 mmol) and ethyl iodide (0.271 mL, 3.35 mmol) were added. The mixture was stirred overnight at room temperature. After adding a saturated ammonium chloride aqueous solution, the reaction mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (heptane/ethyl acetate = 80/20) to give Compound ar (268 mg, 1.06 mmol, 47%). ESI-MS: m/z 252, 254 [M + H]+. 1H-NMR (CDCl3) delta (ppm): 1.39 (t, J = 7.2 Hz, 3H), 4.06 (q, J = 7.2 Hz, 2H), 6.85 (dd, J = 7.7, 1.1 Hz, 1H), 7.17 (d, J = 8.1 Hz, 1H), 7.32 (dd, J = 7.7, 7.7 Hz, 1H), 7.87 (dd, J = 7.7, 1.1 Hz, 1H), 8.41 (d, J = 8.1 Hz, 1H)., 190777-77-6
The synthetic route of 190777-77-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Kyowa Hakko Kirin Co., Ltd.; OTSUBO, Nobumasa; OKAZAKI, Shuko; TSUKUMO, Yukihito; IIDA, Kyoichiro; NAKOJI, Masayoshi; EP2708540; (2014); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem