90806-60-3, 5-Methoxyisoquinoline-1-carbonitrile is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,90806-60-3
Cap-138, step c (0.45 g, 2.44 mmol) was treated with 5N sodium hydroxide solution (10 mL) and the resultingsuspension was heated at 85 C for 4 h, cooled to 25 C, diluted with dichloromethane and acidified with 1N hydrochloricacid. The organic phase was separated, washed with brine, dried over Na2SO4, concentrated to volume and filteredto afford Cap-138 (0.44g, 88.9%) as a yellow solid. 1H NMR (DMSO-d6, 400 MHz) delta 13.6 (br s, 1H), 8.56 (d, J = 6.0 Hz,1H), 8.16 (d, J = 6.0 Hz, 1H), 8.06 (d, J = 8.8 Hz, 1H), 7.71-7.67 (m, 1H), 7.30 (d, J = 8.0 Hz, 1H), 4.02 (s, 3H); Rt = 0.70min (Cond.-D1); 95% homogenity index; LCMS: Anal. Calc. for [M+H]+ C11H10NO3: 204.07; found: 204.05.
As the paragraph descriping shows that 90806-60-3 is playing an increasingly important role.
Reference£º
Patent; Bristol-Myers Squibb Company; BELEMA, Makonen; NGUYEN, Van N.; SERRANO-WU, Michael; ST. LAURENT, Denis R.; QIU, Yuping; DING, Min; MEANWELL, Nicholas A.; SNYDER, Lawrence B.; (149 pag.)EP2328865; (2017); B1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem