With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3482-14-2,Isoquinolin-8-ol,as a common compound, the synthetic route is as follows.
8-hydroxyisoquinoline (3.0 g, 20.69 mmol),PtO2 (0.1 g) was dispersed in glacial acetic acid (100 mL).After the nitrogen was replaced, hydrogen was introduced, and then stirred at 65 C for 2 days.Filtration through celite, and the filtrate was evaporated to dryness under reduced pressure.The residue obtained pure compound 52A (3.12g, 72% yield) crystallized from methanol and diethyl ether,Yellow solid., 3482-14-2
As the paragraph descriping shows that 3482-14-2 is playing an increasingly important role.
Reference£º
Patent; Jiangsu Xiansheng Pharmaceutical Co., Ltd.; Chen Huanming; Liang Bo; Cao Wenjie; Zhang Guiping; Zhao Zhongqiang; Jiang Zhaojian; Zuo Gaolei; Xu Wanmei; Gong Hongju; Zhang Peng; Wang Jianghuai; Li Qingsong; Gao Chunhua; (79 pag.)CN104045552; (2019); B;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem