With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.63927-23-1,5-Bromo-8-nitroisoquinoline,as a common compound, the synthetic route is as follows.
63927-23-1, 8 -Amino iso quino line 5-Bromo-8-mtroisoquinoline (1.00 g, 3.95 mmol) in MeOH (70 mL) was hydrogenated at ambient temperature and pressure over palladium on active carbon (10% Pd, 200 mg) for 18 h. The mixture was filtered through Celite and concentrated.The residue was purified by chromatography (EtOAc :heptane) to give the title compound (100 mg, 18%) as a green-brown solid. 1H NMR (DMSO-de, 400 MHz) delta 9.43 (s, IH), 8.32 (d, IH), 7.54 (d, IH)5 7.40 (dd, IH), 6.99 (d, IH), 6.72 (d, IH), 6.22 (s, 2H).
As the paragraph descriping shows that 63927-23-1 is playing an increasingly important role.
Reference£º
Patent; BIOLIPOX AB; WO2006/32851; (2006); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem