18881-17-9, (S)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,18881-17-9
Intermediate 116(5)-N,N-Dimethyl-2-((l,2 -tetrahydroisoquinolin-3-yl)methoxy)ethanamineIntermediate 116A: (5)-l-(3-(Hydroxymethyl)-3,4-dihydroisoquinolin-2(lH)- yl)ethanone[00362] To (S)-(l,2,3,4-tetrahydroisoquinolin-3-yl)methanol (Aldrich, 350 mg, 2.14 mmol) in EtOAc (4.3 mL) and MeOH (1.1 mL) was added Ac20 (243 mu, 2.57 mmol). The resulting reaction mixture was stirred at room temperature for 2 h. K2CO3 was then added to neutralize the AcOH, and the reaction mixture was filtered through a pad ofCELITE, washing with EtOAc. The filtrate was concentrated in vacuo to give the title compound (316 mg, 72%) as a white solid. lH NMR (CDCI3, 1.5: 1 mixture of amide rotamers) delta 7.26-7.10 (m, 4H), 5.17 (d, J= 18.0 Hz, 0.5H), 4.90 (dt, J= 5.1, 9.4 Hz, 0.5H), 4.66-4.44 (m, 1H), 4.39-4.23 (m, 1H), 3.66-3.55 (m, 1H), 3.55-3.45 (m, 1H), 3.14 (dd, J= 5.9, 16.3 Hz, 0.5H), 3.02 (dd, J= 6.2, 15.8 Hz, 0.5H), 2.92-2.76 (m, 1H), 2.27 (s, 1H), 2.24 (s, 2H); MS(ESI+) m/z 206.1 (M+H)+.
As the paragraph descriping shows that 18881-17-9 is playing an increasingly important role.
Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; BORZILLERI, Robert M.; CAI, Zhen-wei; TEBBEN, Andrew J.; PEREZ, Heidi L.; ZHANG, Liping; SCHROEDER, Gretchen M.; WEI, Donna D.; WO2012/162365; (2012); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem