With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.394-67-2,4-Fluoroisoquinoline,as a common compound, the synthetic route is as follows.
4-Fluoroisoquinoline (3.6 g) obtained in Reference Example 1 was dissolved in concentrated sulfuric acid (20 ml), and the solution was added dropwise with a solution of potassium nitrate (3.25 g, Wako Pure Chemical Industries) in concentrated sulfuric acid (28 ml) under cooling at -5¡ã C. so that the temperature of the reaction mixture should not exceed 5¡ã C. The reaction mixture was stirred at 0¡ã C. for 1 hour, poured into ice water, neutralized with 28percent aqueous ammonia (pH 8), and extracted 3 times with ethyl acetate (150 ml for each time). The combined organic layer was washed with saturated aqueous sodium hydrogencarbonate (300 ml), and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel chromatography (n-hexane:ethyl acetate=3:1) to obtain the title compound (2.2 g)., 394-67-2
The synthetic route of 394-67-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Asahi Kasei Pharma Corporation; US2009/48223; (2009); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem