93117-08-9, Name is 5-Aminoisoquinolin-1(2H)-one, belongs to isoquinoline compound, is a common compound. Computed Properties of C9H8N2OIn an article, once mentioned the new application about 93117-08-9.
Synthesis of 4-alkyl-, 4-aryl- and 4-arylamino-5-aminoisoquinolin-1-ones and identification of a new PARP-2 selective inhibitor
The considerable interest in substituted isoquinolin-1-ones related to 5-aminoisoquinolin-1-one (5-AIQ) as drugs points to a need for an efficient and straightforward synthesis of the 4,5-disubstituted bicycles. Bromination of 5-nitroisoquinolin-1-one gave 4-bromo-5-nitroisoquinolin-1-one but neither this nor 5-amino-4-bromoisoquinolin-1-one would participate in Pd-catalysed couplings. Protection of the lactam as 1-methoxy- and 1-benzyloxy-4-bromo-5- nitroisoquinolines, however, permitted Stille, Suzuki and Buchwald-Hartwig couplings to take place in high yields, insensitive to electronic demands and severe steric bulk in the arylboronic acids. Lithiation of 4-bromo-1-methoxy-5- nitroisoquinoline and quench with iodomethane gave 1-methoxy-4-methyl-5- nitroisoquinoline in low yield. Demethylation of the 1-methoxy-4-substituted-5- nitroisoquinolines with hydrogen bromide gave 4-substituted-5-nitroisoquinolin- 1-ones, whereas hydrogenolytic debenzylation was achieved with simultaneous reduction of the 5-nitro group. 5-Amino-4-(4-trifluoromethylphenyl)isoquinolin- 1-one was identified as a new potent and selective inhibitor of poly(ADP-ribose)polymerase-2 (PARP-2).
Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 93117-08-9
Reference£º
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem