Chemistry is traditionally divided into organic and inorganic chemistry. name: 1-(Bromomethyl)isoquinoline, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 74417-44-0
Trithiocarbonates-Exploration of a new head group for HDAC inhibitors
Inhibition of histone deacetylases class I/II enzymes is a new, promising approach for cancer therapy. In the present study, we disclose a new structural class of HDAC inhibitors with the trithiocarbonate motif. A clear structure-activity-relationship was obtained for the cap-linker motif and the putative Zn2+ complexing head group. Selected analogs display potent inhibition of HDAC enzymatic activity and a cellular potency comparable to that of suberoylanilide hydroxamic acid (SAHA), recently approved for treatment of patients with advanced cutaneous T-cell lymphoma.
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Reference£º
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem