Reference of 63927-23-1, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.63927-23-1, Name is 5-Bromo-8-nitroisoquinoline, molecular formula is C9H5BrN2O2. In a article£¬once mentioned of 63927-23-1
Developing structure-activity relationships from an HTS hit for inhibition of the Cks1-Skp2 protein-protein interaction
Structure-activity relationships have been developed around 5-bromo-8-toluylsulfonamidoquinoline 1 a hit compound in an assay for the interaction of the E3 ligase Skp2 with Cks1, part of the SCF ligase complex. Disruption of this protein-protein interaction results in higher levels of CDK inhibitor p27, which can act as a tumor suppressor. The results of the SAR developed highlight the relationship between the sulfonamide and quinoline nitrogen, while also suggesting that an aryl substituent at the 5-position of the quinoline ring contributes to the potency in the interaction assay. Compounds showing potency in the interaction assay result in greater levels of p27 and have been shown to inhibit cell growth of two p27 sensitive tumor cell lines.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 63927-23-1
Reference£º
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem