Can You Really Do Chemisty Experiments About 6,7-Dimethoxy-3,4-dihydroisoquinoline

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Reaction of methyl bromocycloalkanecarboxylates with zinc and dihydroisoquinoline derivative

The reaction of 5?7-membered methyl 1-bromocycloalkanecarboxylates with zinc and 6,7-dimethoxy-3,4-dihydroisoquinoline leads to 7,8-dimethoxy-5,9b-dihydro-2H,4H-spiro{azeto[2,1-a]isoquinoline-1,1?-cycloalkan}-2-ones. In the case of 1-bromocyclobutanecarboxylate, 9?,10?-dimethoxy-7?,11b?-dihydro-2?H,4?H,6?H-dispiro{cyclobutane-1,1?-pyrido[2,1-a]isoquinoline-3?,1?-cyclobutane}-2?,4?-dione is formed. The structures of the products were confirmed by X-ray diffraction.

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Reference£º
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem