Final Thoughts on Chemistry for 6,7-Dimethoxy-1-methyl-3,4-dihydroisoquinoline

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Molecular structure effects in the asymmetric transfer hydrogenation of functionalized dihydroisoquinolines on (S,S)-[RuCl(eta 6-p-cymene) TsDPEN]

The asymmetric transfer hydrogenation of five dihydroisoquinolines (DHIQs) was studied by NMR spectroscopy. The DHIQs differed by substitution with methoxy groups, which had a significant effect upon the reaction performance in terms of reaction rate and enantioselectivity. The differences are most probably related to the basicity of DHIQs.

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Reference£º
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem