The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Category: isoquinoline, 521284-21-9, Name is (R)-2-((4-Nitrophenethyl)amino)-1-phenylethanol hydrochloride, SMILES is O=[N+](C1=CC=C(C=C1)CCNC[C@H](O)C2=CC=CC=C2)[O-].[H]Cl, in an article , author is Deady, LW, once mentioned of 521284-21-9.
Synthesis and reactivity of some imidazo-, triazolo- and tetrazolo-isoquinoline derivatives
1-Acetylimino-3-methyl-1H-isochromene-4-carbonitrile, 1, reacts with glycine ethyl ester under basic conditions to give an imidazo[2,1-a]isoquinoline derivative, while reaction with hydrazine hydrate in 1,4-dioxane, with further chemistry, provides access to [1,2,4]triazolo[5,1-a]isoquinoline, [1,2,4]triazolo[3,4a]isoquinoline and tetrazolo[5,1-a]isoquinoline analogs. Benzene ring nitration and radical bromination of substituent methyl groups were investigated in the four tricycles, with some different positional reactivities being found. Two bromomethyl derivatives so produced were oxidised; ethyl 2-bromomethyl-6-cyano-5-methylimidazo[2,1-a]isoquinoline-3-carboxylate gave the anticipated ethyl 6-cyano-2-formyl-5-methylimidazo[2,1-a]isoquinoline-3-carboxylate (which reacted further with hydrazine to form a new system, 8,9-dihydro-6-methyl-8-oxopyridazino[4′,5′:4,5]imidazo[2,1-a]isoquinoline-5-carbonitrile), while 5-bromomethyl-2-methyl[1,2,4]triazolo[5,1-a]isoquinoline-6-carbonitrile unexpectedly gave directly another new system, 5,6-dihydro-5-hydroxy-2-methyl-7H-pyrrolo[3,4-c][1,2,4]triazolo[5,1-a]isoquinolin-7-one.
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Reference:
Isoquinoline – Wikipedia,
,Isoquinoline | C9H7N – PubChem