The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 1721-93-3, Name is 1-Methylisoquinoline, SMILES is CC1=NC=CC2=C1C=CC=C2, in an article , author is Yu, Minhui, once mentioned of 1721-93-3, Computed Properties of C10H9N.
First diastereoselective synthesis of perfluoroalkylated cis-spiropyrido [2,1-a] isoquinoline-1,5′-pyrimidines
The 1,4-dipoles derived from isoquinolines and methyl perfluoroalk-2-ynoates reacted readily with arylidene-substituted N,N-dimethylbarbituric acids resulting in the first diastereoselective synthesis of perfluoroalkylated cis-spiropyrido[2,1-a]isoquinoline-1,5′-pyrimidine derivatives in good to excellent yields under mild conditions. The reaction mechanism was proposed to illustrate the formation of the diastereoisomers and proton-promoted transformation of trans-spiropyrido[2,1-a]isoquinoline-1,5′-pyrimidines to the more thermodynamically stable cis-isomers. The DFT calculation demonstrated the diastereoselectivity of the reaction.
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Reference:
Isoquinoline – Wikipedia,
,Isoquinoline | C9H7N – PubChem