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Fast regioselective sulfonylation of pyridine/quinoline N-oxides induced by iodine
Fast sulfonylation of pyridine/quinoline N-oxides induced by iodine is demonstrated herein. The regioselective protocol occurs under metal-free conditions in a short reaction time (10 min), exhibiting high efficiency (up to 92% yield) and good compatibility (up to 33 examples). A gram-scale reaction was conducted with only a slight loss of production.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Recommanded Product: Isoquinoline N-Oxide, you can also check out more blogs about1532-72-5
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Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem