Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 21806-61-1, Name is Prop-1-ene-1,3-sultone, molecular formula is , belongs to isoquinoline compound. In a document, author is Nishikawa-Shimono, Rie, Recommanded Product: 21806-61-1.
Isoquinoline Derivatives as Potent, Selective, and Orally Active CRTH2 Antagonists
Synthesis and structure activity relationship of a novel series of isoquinoline CRTH2 antagonists bearing a methylene linker between the isoquinoline and benzamide moieties were described. Optimization focusing on the substituents of the benzamide portion in the right hand part of the molecule led to the identification of TASP0412098 (91), which is a potent, selective CRTH2 antagonist (binding affinity: IC50=2.1 nm, functional activity: IC50=12 nm). Compound 91, which was orally bioavailable in mice and guinea pigs, showed in vivo efficacy after oral administration in a bronchial asthma model of guinea pigs.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 21806-61-1, in my other articles. Recommanded Product: 21806-61-1.
Reference:
Isoquinoline – Wikipedia,
,Isoquinoline | C9H7N – PubChem