Synthetic Route of 1721-93-3, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 1721-93-3, Name is 1-Methylisoquinoline, SMILES is CC1=NC=CC2=C1C=CC=C2, belongs to isoquinoline compound. In a article, author is Schuetz, Ramona, introduce new discover of the category.
Racemic total synthesis and evaluation of the biological activities of the isoquinoline-benzylisoquinoline alkaloid muraricine
The first racemic total synthesis of the isoquinoline-benzylisoquinoline alkaloid muraricine is reported herein. Pharmacological characterization identified muraricine as a moderate inhibitor of P-glycoprotein, a crucial factor of multidrug resistance in cancer. When combined with vincristine, muraricine partly reversed the chemoresistance of vincristine-resistant leukemia cells at a nontoxic concentration. Furthermore, no cytotoxic effects on noncancerous human cells in therapeutically relevant concentrations were observed.
Synthetic Route of 1721-93-3, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 1721-93-3.
Reference:
Isoquinoline – Wikipedia,
,Isoquinoline | C9H7N – PubChem