Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Formula: C3H4O3S, 21806-61-1, Name is Prop-1-ene-1,3-sultone, SMILES is O=S1(C=CCO1)=O, belongs to isoquinoline compound. In a document, author is Zhang, Yuan-Yuan, introduce the new discover.
Construction of Spiropyrido[2,1-a]isoquinoline via Tandem Reactions of Huisgen’s 1,4-Dipoles with Various Alkene Dipolarophiles
The three-component reaction of isoquinoline, dimethyl acetylenedicarboxylate and arylidene pivaloylacetonitrile in acetonitrile at room temperature afforded pyrido[2,1-a]isoquinolines 1a-1j in good yields and with high diastereoselectivity. When arylidene-substituted 1,3-indanediones, Meldrum acids, and N,N’-dimethylbarbituric acids were employed in the reaction, the novel functionalized spiro[indene-2,1-pyrido[2,1-a]isoquinolines] 2a-2j, spiro[pyrido[2,1-a]isoquinoline-1,5-[1,3]dioxanes] 3a-3h and spiro[pyrido[2,1-a]isoquinoline-1,5-pyrimidines] 4a-4e were also efficiently synthesized in satisfactory yields. The reaction mechanism included domino formation of Huisgen’s 1,4-dipole, Michael addition and cyclization processes.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 21806-61-1. Formula: C3H4O3S.
Reference:
Isoquinoline – Wikipedia,
,Isoquinoline | C9H7N – PubChem