In heterogeneous catalysis, the catalyst is in a different phase from the reactants. name: 6-Bromo-3,4-dihydroisoquinolin-1(2H)-one, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 147497-32-3, name is 6-Bromo-3,4-dihydroisoquinolin-1(2H)-one. In an article£¬Which mentioned a new discovery about 147497-32-3
Discovery of thieno[2,3-d]pyrimidin-4(3H)-one derivatives as a new class of ROCK inhibitors
Herein, we report the discovery of a series of thieno[2,3-d]pyrimidin-4(3H)-one derivatives as a new class of ROCK inhibitors. Structure-activity relationship studies of these compounds led to the identification of the most potent compound, 3-(3-methoxybenzyl)-6-(1H-pyrrolo[2,3-b]pyridin-4-yl)thieno[2,3-d]pyrimidin-4(3H)-one (8k), which showed IC50 values of 0.004 muM and 0.001 muM against ROCK ? and ROCK ?, respectively. In vitro, 8k significantly reduced the phosphorylation level of ROCK downstream signaling protein and induce changes in cell morphology and migration. Overall, this study provides a promising lead compound for drug discovery targeting ROCKs.
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Reference£º
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem