6624-49-3, Name is Isoquinoline-3-carboxylic acid, belongs to isoquinoline compound, is a common compound. Recommanded Product: 6624-49-3In an article, once mentioned the new application about 6624-49-3.
Structure-activity relationship of boronic acid derivatives of tyropeptin: Proteasome inhibitors
The structure-activity relationship of the boronic acid derivatives of tyropeptin, a proteasome inhibitor, was studied. Based on the structure of a previously reported boronate analog of tyropeptin (2), 41 derivatives, which have varying substructure at the N-terminal acyl moiety and P2 position, were synthesized. Among them, 3-phenoxyphenylacetamide 6 and 3-fluoro picolinamide 22 displayed the most potent inhibitory activity toward chymotryptic activity of proteasome and cytotoxicity, respectively. The replacement of the isopropyl group in the P2 side chain to H or Me had negligible effects on the biological activities examined in this study.
Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 6624-49-3
Reference£º
Isoquinoline – Wikipedia,
Isoquinoline | C9H1759N – PubChem