3382-18-1, Name is 6,7-Dimethoxy-3,4-dihydroisoquinoline, belongs to isoquinoline compound, is a common compound. Safety of 6,7-Dimethoxy-3,4-dihydroisoquinolineIn an article, once mentioned the new application about 3382-18-1.
Synthesis of alkaloids by stevens rearrangement of nitrile-stabilized ammonium ylides: (¡À)-laudanosine, (¡À)-laudanidine, (¡À)-armepavine, (¡À)-7-methoxycryptopleurine, and (¡À)-xylopinine
The Stevens rearrangement of nitrile-stabilized ammonium ylides in conjunction with the reductive removal of the nitrile function permits the facile construction of alpha-branched amines from alpha-aminonitriles. We employed this reaction sequence for the preparation of (¡À)-laudanosine, (¡À)-laudanidine and (¡À)-armepavine, (¡À)-7- methoxycryptopleurine, and (¡À)-xylopinine from two closely related and readily accessible bicyclic alpha-aminonitriles. The final products were obtained in high to almost quantitative yields (71-98%) from the quaternary ammonium salts obtained by N-alkylation of these starting materials.
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Reference£º
Isoquinoline – Wikipedia,
Isoquinoline | C9H2376N – PubChem