The Absolute Best Science Experiment for 7-Bromoisoquinoline

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Discovery of Potent, Efficient, and Selective Inhibitors of Phosphoinositide 3-Kinase delta through a Deconstruction and Regrowth Approach

A deconstruction of previously reported phosphoinositide 3-kinase delta (PI3Kdelta) inhibitors and subsequent regrowth led to the identification of a privileged fragment for PI3Kdelta, which was exploited to deliver a potent, efficient, and selective lead series with a novel binding mode observed in the PI3Kdelta crystal structure.

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Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem