Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Safety of tert-Butyl 7-fluoro-6-nitro-3,4-dihydroisoquinoline-2(1H)-carboxylate. Introducing a new discovery about 912846-67-4, Name is tert-Butyl 7-fluoro-6-nitro-3,4-dihydroisoquinoline-2(1H)-carboxylate
3-SULFONYLAMINO-PYRROLIDINE-2-ONE DERIVATIVES AS FACTOR XA INHIBITORS
The present invention provides at least one chemical entity chosen from compounds of formula (I) wherein: R1 represents a group selected from formula (II), (III), (IV), (V), (VI), (VII), each ring of which optionally contains a further heteroatom N, Z represents an optional substituent halogen, -C1-3alkyl or -NRaRb, alk represents alkylene or alkenylene, T represents S, O or NH; Ra and Rb independently represent hydrogen or -C1-3alkyl; R2 represents a group selected from formula (VIII), (IX), W, X and Y independently represent CH, C-R5 or N; R5 represents halogen or C1-3alkyl; V represents NR3, S or O; R3 represents hydrogen or C1-3alkyl; one of A1 and A2 represents N and the other represents CH; Each R4, R6, R7, R8, R9 independently represents hydrogen or C1-3alkyl; R10 represents hydrogen, -C1-6alkyl, -C1-3alkylCONRaRb, -C1-3alkylCO2C1-4alkyl, -CO2C1-4alkyl or -C1-3alkylCO2H; and pharmaceutically acceptable derivative(s) thereof. The invention also relates to processes for the preparation of compound(s) of formula (I), pharmaceutical compositions containing compound(s) of formula (I) and to the use of compound(s) of formula (I) in medicine, particularly in the amelioration of a clinical condition for which a Factor Xa inhibitor is indicated.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Safety of tert-Butyl 7-fluoro-6-nitro-3,4-dihydroisoquinoline-2(1H)-carboxylate, you can also check out more blogs about912846-67-4
Reference：
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem