A new application about 6,7-Dimethoxy-1-methyl-3,4-dihydroisoquinoline

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.category: isoquinoline, you can also check out more blogs about4721-98-6

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. category: isoquinoline. Introducing a new discovery about 4721-98-6, Name is 6,7-Dimethoxy-1-methyl-3,4-dihydroisoquinoline

The substitution of a methoxy group by a methylamino group in 3,4-dihydroisoquinolines, catalyzed by ammonium chloride, takes place when the methoxy group is at the para position but not at the meta position to the imino group, which is a structural fragment of the bicyclic system. 1-Methylisoquinolinium salts containing a methoxy group at position 6 or 7 undergo recyclization to naphthalene derivatives under the influence of an alcohol solution of methylamine, and the 6-methoxy group is substituted by a methylamino group.In isoquinolines the reactivity of the methoxy group toward methylamine is significantly lower.Substitution in 6- and 7-methoxyisoquinolines takes place with the initial formation of hydroxyisoquinolines followed by substitution of the hydroxyl group by a methylamino group.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.category: isoquinoline, you can also check out more blogs about4721-98-6

Reference：
Isoquinoline – Wikipedia,
Isoquinoline | C9H2765N – PubChem