Related Products of 3382-18-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.3382-18-1, Name is 6,7-Dimethoxy-3,4-dihydroisoquinoline, molecular formula is C11H13NO2. In a Article，once mentioned of 3382-18-1
Analogues of the potent alpha2-adrenoceptor antagonist (8aR,12aS,13aS)-5,8,8a,9,10,11,12,12a,13,13a-decahydro-3-methoxy-12- (methylsulfonyl)-6H-isoquino[2,1-g][1,6]naphthyridine (1b) were prepared and evaluated for alpha1- and alpha2-adrenoceptor affinity. Affinity for alpha2-adrenoceptors was assessed by displacement of [3H]yohimbine from rat cerebral cortical membranes and although 1b and close structural analogues demonstrated high affinity, none were selective for the alpha(2A) or alpha(2B) subtypes reputedly present in this tissue. All of the high affinity alpha2-adrenoceptor ligands were, however, selective with respect to [3H]prazosin (alpha1) binding. Affinity for [3H]yohimbine-labeled alpha2-adrenoceptors was found to be highly dependent on the stereochemistry of the tetracyclic system. The 8abeta,12aalpha,13aalpha diastereomer of 1 (56) had moderate affinity for alpha2-adrenoceptors while the 8abeta,12abeta,13aalpha diastereomer (55) had very low affinity. The affinity and selectivity of these agents for alpha2-adrenoceptors was found to correspond to that observed for several isomeric yohimbine analogues which have similar relative and absolute stereochemistries. Deviation from the structure of 1 by opening the B ring, changing the position of the sulfonamide nitrogen, or changing the attachment of the D ring led to a dramatic decrease in alpha2-adrenoceptor affinity. High binding affinity was found to correlate with functional antagonism in the guinea pig ileum. The reversal of clonidine-induced mydriasis in the rat was used to assess bioavailability and indicated that 1b was a potent alpha2-adrenoceptor antagonist in vivo.
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Reference：
Isoquinoline – Wikipedia,
Isoquinoline | C9H2251N – PubChem