19493-44-8, Name is 1-Chloroisoquinoline, belongs to isoquinoline compound, is a common compound. category: IsoquinolinesIn an article, once mentioned the new application about 19493-44-8.
We have prepared a series of piperazinylpyridine derivatives for the treatment of irritable bowel syndrome (IBS). These compounds, which were designed by pharmacophore analysis, bind to both serotonin subtype 1A (5-HT 1A) and subtype 3 (5-HT3) receptors. The nitrogen atom of the isoquinoline, a methoxy group and piper-azine were essential to the pharmacophore for binding to these receptors. We also synthesized furo- and thienopyridine derivatives according to structure-activity relationship analyses. Compound 17c (TZB-20810) had high affinities to these receptors and exhibited 5-HT1A agonistic activity and 5-HT3 antagonistic activity concurrently, and is a promising drug for further development in the treatment of IBS.
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Reference：
Isoquinoline – Wikipedia,
Isoquinoline | C9H1255N – PubChem