Archives for Chemistry Experiments of 1-Methyl-3,4-dihydroisoquinoline

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The reaction of 1-methyl-3,4-dihydroisoquinolinium salts with acrylamide forms 2-(2-carbamoylethyl)-1-methyl-3,4-dihydroisoquinolinium salts, which are cyclized by the action of bases to form 11b-methyl-1,2,3,6,7,11b-hexahydro-4H-pyrimido<2,1-a>isoquinolin-2-one.Treatment of this compound with iodomethane yields 5,11b-dimethyl-2-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrimido<2,1-a>isoquinolinium iodide.The 11b-methylpyrimido<2,1-a>isoquinolin-2-one enters into condensation with aromatic aldehydes, forming the corresponding styryl compounds.

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Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem