In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Application In Synthesis of Isoquinolin-8-ol, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 3482-14-2, name is Isoquinolin-8-ol. In an article，Which mentioned a new discovery about 3482-14-2
8 – hydroxy isoquinoline synthesis method, which belongs to the isoquinoline compound of synthetic method field. Comprises the following steps: in the dimethyl sulfoxide and water mixed solution 8 – chloroisonicotinic quinoline, copper acetylacetonate, a hydrated hydrogen lithia and ligand 1, 3 – double-(4 – hydroxy – 2, 6 – dimethyl-phenyl) urea; under the protection of nitrogen, reaction nearby fluid material to the heating side stirring until the reaction is completed; to be agitated after cooling after the reaction of, for acidification to pH=5 HCl; the mixed liquid ethyl acetate extraction, the extraction of the organic phase with saturated salt water washing, after drying by anhydrous sodium sulfate turns on lathe does, the crude product by column chromatography separation latter system 8 – hydroxy isoquinoline. The invention provides a method for 8 – chloroisonicotinic quinoline as raw materials, simple synthetic route, the craft choice is rational, and is simple, operation and after treatment is convenient, total yield up to 72%, easy to enlarge, can be large-scale production of 8 – hydroxy isoquinoline synthesis method. (by machine translation)
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Reference：
Isoquinoline – Wikipedia,
Isoquinoline | C9H382N – PubChem