23687-27-6, Name is Isoquinolin-8-amine, belongs to isoquinoline compound, is a common compound. HPLC of Formula: C9H8N2In an article, once mentioned the new application about 23687-27-6.
Nitric Oxide Synthase (NOS) inhibitors could play a powerful role in inflammatory and neurodegenerative diseases. In this work, novel acetamidine derivatives of NOS were synthesized and the inhibitor activity was evalued. To screen the activity and selectivity, the l-citrulline residue, after the enzymatic NOS assay, was derivatized with o-phthaldialdehyde/N-acetyl cysteine (OPA/NAC) and then evaluated by RP-HPLC method with fluorescence detection.All compounds did not affect the activity of endothelial and neuronal isoforms, while nine of them possessed a percentage of iNOS activity at 10 muM lower than 50%, and were selected for IC50 evaluation. Among them, a compound emerged as a very potent (IC50 of 53 nM) and selective iNOS inhibitor.
Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 23687-27-6
Reference：
Isoquinoline – Wikipedia,
Isoquinoline | C9H278N – PubChem