6624-49-3, Name is Isoquinoline-3-carboxylic acid, belongs to isoquinoline compound, is a common compound. Safety of Isoquinoline-3-carboxylic acidIn an article, once mentioned the new application about 6624-49-3.
A series of benzylamides of isocyclic and heterocyclic acids was synthesized and tested in Anticonvulsant Screening Project (ASP) of Antiepileptic Drug Development Program (ADDP) of NIH. Near all synthesized derivatives of heterocyclic acids showed activity. All obtained derivatives of mono- and bicyclic isocyclic acids were inactive. The power of action of heterocyclic acids derivatives seems does not depend upon kind of heteroatom (N, O or S). One of the compounds (2-furoic acid benzylamide (4)) appeared most promising. It showed in minimal clonic seizure (6Hz) test (ASP) in rats after i. p. administration: MES ED50 = 36.5 mg/kg, TOX TD50 = 269.75 mg/kg, and PI = 7.39.
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Reference：
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem